Characterization of Fractalkine in Rat Brain
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Synovial fractalkine plays important role in cytokines’ related knee edema variation in rat arthritis model
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Fractalkine is a CX3C-family chemokine, highly and constitutively expressed on the neuronal cell surface, for which a clear CNS physiological function has yet to be determined. Its cognate receptor, CX3CR-1, is constitutively expressed on microglia, the brain-resident macrophages; however, these cells do not express fractalkine. We now show that treatment of microglia with fractalkine maintains...
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تاریخ انتشار 1999